(S)-5'-S-[4-Methoxy-4-oxo-3-[(trifluoroacetyl)amino]butyl]-5'-thioadenosine-13C5 is an intermediate in the synthesis of S-(5'-Adenosyl)-L-homocysteine-13C5 (A291502), which is a novel labelled biomarker for predicting susceptibility of a subject to a mental or neurodegenerative disorder.