Basic information Safety Related Supplier

DIHYDROSAFROL

Basic information Safety Related Supplier
DIHYDROSAFROL Basic information
DIHYDROSAFROL Chemical Properties
  • Boiling point:251.67°C (rough estimate)
  • Density 1.0326 (rough estimate)
  • refractive index 1.5320 (estimate)
  • CAS DataBase Reference94-58-6
  • IARC2B (Vol. 10, Sup 7) 1987
  • EPA Substance Registry SystemDihydrosafrole (94-58-6)
Safety Information
DIHYDROSAFROL Usage And Synthesis
  • Chemical PropertiesLight Yellow Oil
  • OccurrenceHas apparently not been reported to occur in nature.
  • UsesSafrole derivative. Carcinogenic.
  • PreparationBy catalytic hydrogenation of safrole (Arctander, 1969).
  • Toxicity evaluationThe acute oral LD50 was reported as 2.26 g/kg (1.84-2.78 g/kg) in rats and as 4.30 g/kg in the mouse (Jenner, Hagan, Taylor, Cook & Fitzhugh, 1964). The acute dermal LD50 in rabbits was reported as > 5 g/kg (Shelanski & Moldovan, 1973). Daily dosage for 4 days with 770 mg dihydrosafrole/kg caused macroscopic liver lesions and one death in six treated rats (Taylor, Jenner & Jones, 1964).
  • General DescriptionOily liquid.
  • Health HazardInhalation of material may be harmful. Contact may cause burns to skin and eyes. Inhalation of Asbestos dust may have a damaging effect on the lungs. Fire may produce irritating, corrosive and/or toxic gases. Some liquids produce vapors that may cause dizziness or suffocation. Runoff from fire control may cause pollution.
  • Fire HazardSome may burn but none ignite readily. Containers may explode when heated. Some may be transported hot.
  • Safety ProfileConfirmed carcinogen with experimental carcinogenic data. Moderately toxic by ingestion and intraperitoneal routes. A skin irritant. When heated to decomposition it emits acrid smoke and irritating fumes.
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