AS8351
AS8351 性质
| 熔点 | 180-182 °C (decomp)(Solvent: Ethanol) |
|---|---|
| 密度 | 1.270±0.14 g/cm3(Temp: 25 °C; Press: 760 Torr)(predicted) |
| 储存条件 | Inert atmosphere,Store in freezer, under -20°C |
| 溶解度 | 溶于DMSO(45mg/ml)；乙醇（10mg/ml加热） |
| 形态 | 固体 |
| 酸度系数(pKa) | 8.203±0.50(predicted) |
| 颜色 | 粘黄色 |
| 稳定性 | 可在-20°C下的DMSO或乙醇溶液保存长达3个月。 |
| InChI | 1S/C17H13N3O2/c21-16-6-5-12-3-1-2-4-14(12)15(16)11-19-20-17(22)13-7-9-18-10-8-13/h1-11,21H,(H,20,22)/b19-11+ |
| InChIKey | WQSHHAVECQJKLX-YBFXNURJSA-N |
| SMILES | OC1=CC=C(C=CC=C2)C2=C1/C=N/NC(C3=CC=NC=C3)=O |
AS8351 用途与合成方法
KDM5B
AS8351 affects epigenetic modifications by competing with α-ketoglutarate (α-KG) for chelating iron [Fe(II)] in certain epigenetic enzymes, such as the JmjC domain-containing histone demethylases (JmjC-KDMs) that require α-KG and iron as co-factors.
54-85-3
708-06-5
796-42-9
H2La、H2Lb和H2Lc的合成采用标准方法：将等摩尔量的异烟酰肼（吡啶-4-甲酰肼）与相应的醛（5-溴-2-羟基苯甲醛、2-羟基-1-萘甲醛或2,4-二羟基苯甲醛）在乙醇中回流反应3小时，随后冷却至室温。通过缓慢蒸发化合物的稀乙醇溶液，获得适用于X射线晶体学分析的晶体。
参考文献：
[1] European Journal of Inorganic Chemistry, 2017, vol. 2017, # 6, p. 999 - 1006
[2] Polyhedron, 2014, vol. 79, p. 88 - 96
[3] Spectrochimica Acta - Part A: Molecular and Biomolecular Spectroscopy, 2006, vol. 64, # 4, p. 853 - 858
[4] Medicinal Chemistry Research, 2014, vol. 23, # 1, p. 269 - 279
[5] Journal of the American Chemical Society, 1953, vol. 75, p. 5434
AS8351 价格(试剂级)
| 更新日期 | 产品编号 | 产品名称 | CAS号 | 包装 | 价格 |
|---|---|---|---|---|---|
| 2026-09-15 | HY-100744 | AS8351 | 796-42-9 | 5mg | 495 |
| 2026-09-15 | HY-100744 | AS8351 | 796-42-9 | 10mM * 1mLin DMSO | 544 |
