m-PEG3-ONHBoc contains a Boc protected aminooxy group. The Boc can be removed under acidic conditions to be further reacted. The hydrophilic PEG chain increases the water solubility of the compound in aqueous media.
Uses
m-PEG3-aminooxy-Boc is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].
IC 50
PEGs; Alkyl/ether
References
[1] An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562 DOI:10.1016/j.ebiom.2018.09.005
