ML154 (NCGC84; 1 mg/kg; i.p; once) blocks alcohol-induced ERK-phosphorylation in the rat central amygdala, a region involved in regulation of alcohol intake. ML154 also decreases operant alcohol self-administration, and lowers motivation for alcohol reward as measured using progressive ratio responding[1].
| Animal Model: | Male Wistar rats (300-350 g) injected with alcohol[1] |
| Dosage: | 1 mg/kg (10% Solutol, 10% N,N-dimethylacetamide, and 80% 10 mM PBS, pH 7.4) |
| Administration: | Intraperitoneal injection; once |
| Result: | Inhibited alcohol-induced central ERK phosphorylation in vivo. |
