S-acetyl-PEG4-alcohol

S-acetyl-PEG4-alcohol is a PEG linker containing a sulfur acetyl group which can be deprotected to form thiol groups. The hydroxyl group can undergo various reactions to further derivatize the compound. The hydrophilic PEG linker increases the water solubility of the compound in aqueous media.

S-acetyl-PEG4-alcohol is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

PEGs

[1] An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562 DOI:10.1016/j.ebiom.2018.09.005