2-Chlorostearic acid

2-chloro Stearic acid is a bioactive fatty acid that accumulates in primary human monocytes and neutrophils as well as murine neutrophils stimulated with phorbol 12-myristate 13-acetate (PMA; ).^1,2 It induces DNA release from primary human neutrophils.² 2-chloro Stearic acid is toxic to C. quinquefasciatus larvae (LC₅₀ = <1 ppm).³

1. Wang, W.Y., Albert, C.J., and Ford, D.A. α-Chlorofatty acid accumulates in activated monocytes and causes apoptosis through reactive oxygen species production and endoplasmic reticulum stress Arterioscler. Thromb. Vasc. Biol. 34(3),526-532(2014).
2. Palladino, E.N.D., Katunga, L.A., Kolar, G.R., et al. 2-Chlorofatty acids: Lipid mediators of neutrophil extracellular trap formation J. Lipid. Res. 59(8),1424-1432(2018).
3. Hwang, Y.-S., Darwazeh, H.A., and Navvab Gojrati, H.A. Overcrowding factors of mosquito larvae - larvicidal activity of substituted alkanoic acids and their esters Proc. Pap. Annu. Conf. Calif. Mosq. Control Assoc. 45,160-161(1977).