2H-1-Benzopyran-2-one, 7-hydroxy-5-Methoxy-4-Methyl-3-(4-Methyl-1-piperazinyl)-

IMM-H004, a coumarin derivative, possesses neuroprotective and potent free radical scavenging abilities. IMM-H004 significantly inhibits amyloid-β (Aβ)-induced cytotoxicity and apoptosis, offering potential value for research into neurodegenerative diseases such as Alzheimer's disease. Additionally, IMM-H004 is also capable of effectively blocking the calcium mobilization and chemotaxis induced by CKLF1-C27 (HY-P3418), thereby alleviating asthmatic pathological changes in the lung tissue of CKLF1 transgenic mice[1].

[1] Song X Y, et al. IMM-H004, a novel coumarin derivative compound, protects against amyloid beta-induced neurotoxicity through a mitochondrial-dependent pathway[J]. Neuroscience, 2013, 242: 28-38. DOI:10.1016/j.neuroscience.2013.02.049