Moxidectin-d3

Moxidectin-d3 is intended for use as an internal standard for the quantification of moxidectin (Item No. 17165) by GC- or LC-MS. Moxidectin is a macrocyclic lactone endectocide and a derivative of nemadectin.1,2 It reduces fecal nematode egg counts by 98.4 and 99.8% in naturally infected calves when administered subcutaneously at doses of 0.2 and 0.3 mg/kg, respectively.2 Moxidectin (0.2 and 0.3 mg/kg) reduces worm burden of O. ostertagi and T. axei in the abomasum, and Cooperia species and N. helvetianus in the small intestine, of naturally infected calves. It potentiates GABA-gated currents in Xenopus oocytes expressing rat α1β2γ2 subunit-containing GABAA receptors with an EC50 value of 11.8 nM.3 Formulations containing moxidectin have been used in the treatment of onchocerciasis, as well as in the prevention and treatment of parasitic infections in veterinary medicine.WARNING This product is not for human or veterinary use.

[1] ASHOK KUMAR . The sphingolipid degradation product trans-2-hexadecenal induces cytoskeletal reorganization and apoptosis in a JNK-dependent manner[J]. Cellular signalling, 2011, 23 7: Pages 1144-1152. DOI: 10.1016/j.cellsig.2011.02.009
[2] S. RANJAN . Efficacy of moxidectin against naturally acquired nematode infections in cattle[J]. Veterinary parasitology, 1992, 41 3: Pages 227-231. DOI: 10.1016/0304-4017(92)90082-k
[3] CÉCILE MÉNEZ. Relative neurotoxicity of ivermectin and moxidectin in Mdr1ab (-/-) mice and effects on mammalian GABA(A) channel activity.[J]. PLoS Neglected Tropical Diseases, 2012, 6 11: e1883. DOI: 10.1371/journal.pntd.0001883