AMP 397 is a potent AMPA antagonist and an antiepileptic drug.
in vitro
AMP 397 is negative in a mouse lymphoma tk assay, which includes a 24 h treatment without S9. A weak micronucleus induction in vitro is found at the highest concentrations tested in V79 cells with S9.
in vivo
AMP 397 is negative in the following in vivo studies, which includes the maximum tolerated doses of 320 mg/kg in mice and 2000 mg/kg in rats. It has no genotoxic potential in vivo.
