JWH 200 is a 3-
indolyl-
1-
naphthylmethane that acts as a cannabinoid (CB) receptor agonist, binding to the CB
1 receptor with high affinity (IC
50 = 42 nM).
1 This synthetic cannabinoid has been identified as an adulterant of herbal blends.
2 JWH 200 2’-
naphthyl isomer differs structurally from JWH 200 by having the naphthyl group attached at the 2’ position. The biological and toxicological properties of this compound have not been characterized. This product is intended for forensic purposes.
1. Huffman, J.W., Mabon, R., Wu, M.J., et al. 3-indolyl-1-naphthylmethanes: New cannabimimetic indoles provide evidence for aromatic stacking interactions with the CB1 cannabinoid receptor Bioorgan. Med. Chem. 11(4),539-549(2003).
2. Kikura-Hanajiri, R., Uchiyama, N., and Goda, Y. Survey of current trends in the abuse of psychotropic substances and plants in Japan Leg. Med. (Tokyo) 13(3),109-115(2011).
