CAY10654

The gram-negative pathogen Pseudomonas aeruginosa uses N-acylated-L-homoserine lactones (AHLs) in quorum sensing to modulate transcriptional activators, including LasR, and regulate the expression of virulence factors. The same AHLs suppress the host immune system. CAY10654 is a synthetic analog of natural AHLs that suppresses host immunity without inducing LasR.¹ It inhibits the proliferation of mouse peripheral blood leukocytes by concanavalin A (EC₅₀ = 9.3 μM) without concurrent cytotoxicity.¹ LasR is not induced by 100 μM CAY10654, although LasR is potently induced by natural AHL (5 μM) in positive control experiments.¹

ChEBI: CAY10654 is an anilide.

1. Jadhav, G.P., Chhabra, S.R., Telford, G., et al. Immunosuppressive but non-LasR-inducing analogues of the Pseudomonas aeruginosa quorum-sensing molecule N-(3-oxododecanoyl)-L-homoserine lactone J. Med. Chem. 54(9),3348-3359(2011).