(±)8(9)-EET ethanolamide is a CYP450 metabolite of AEA, although specific stereochemistry rather than a racemic mixture would likely ensue from enzymatic metabolism.1 Human liver microsomes metabolize AEA to 5,6-, 8,9-, 11,12-, and 14,15-EET ethanolamides in a time and protein concentration dependent manner.1 (±)8(9)-EET reduces glomerular filtration rate through cyclooxygenase dependent preglomerular vasoconstriction.2 The physiological actions of (±)8(9)-EET ethanolamide have not been examined.WARNING This product is not for human or veterinary use.
[1] NATASHA T SNIDER. Anandamide metabolism by human liver and kidney microsomal cytochrome p450 enzymes to form hydroxyeicosatetraenoic and epoxyeicosatrienoic acid ethanolamides.[J]. Journal of Pharmacology and Experimental Therapeutics, 2007, 321 2: 590-597. DOI:
10.1124/jpet.107.119321[2] T KATOH. Glomerular stereospecific synthesis and hemodynamic actions of 8,9-epoxyeicosatrienoic acid in rat kidney.[J]. American Journal of Physiology, 1991, 261 4 Pt 2: F578-86. DOI:
10.1152/ajprenal.1991.261.4.f578
