Octyl glucose neopentyl glycol (OGNG) is a neopentyl glycol detergent that can be used to maintain the stability of membrane proteins[1].
The decisive step, in the improvement of Thermotoga maritima (TmPPase) crystal quality came through detergent exchange in to Octyl glucose neopentyl glycol, a neopentyl glycol detergent[1].
[1]. Juho Kellosalo, et al. Crystallization and preliminary X-ray analysis of membrane-bound pyrophosphatases. Mol Membr Biol. 2013 Feb;30(1):64-74. [2]. Muhammad Ehsan, et al. New Malonate-Derived Tetraglucoside Detergents for Membrane Protein Stability. ACS Chem Biol. 2020 Jun 19;15(6):1697-1707.
