6-Amino-2,3-dihydro-5-[(phenylmethylene)amino]-2-4(1H)-pyrimidineone

L189 is a competitive inhibitor of DNA ligases I, III, and IV (IC₅₀s = 5, 9, and 5 μM, respectively). It blocks DNA binding (K_i = 5 μM for DNA ligase I), increasing the cytotoxicity of DNA-damaging agents, including ionizing radiation. L189 preferentially inhibits the interaction of the ligase with damaged DNA, inhibiting base excision repair and non-homologous end-joining.

L189 has been shown to inhibit DNA ligases I, III, and IV and may have potential use in the development of anticancer agents.

Store at -20°C

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