4-[(1E)-2-[5,6-Dihydro-5,5-dimethyl-8-(2-phenylethynyl)-2-naphthalenyl]ethenyl]benzoicacid
4-[(1E)-2-[5,6-Dihydro-5,5-dimethyl-8-(2-phenylethynyl)-2-naphthalenyl]ethenyl]benzoicacid
英文名称:4-[(1E)-2-[5,6-Dihydro-5,5-dimethyl-8-(2-phenylethynyl)-2-naphthalenyl]ethenyl]benzoicacid
CAS号:215030-90-3
分子式:C29H24O2
分子量:404.5
EINECS号:
Mol文件:215030-90-3.mol
![4-[(1E)-2-[5,6-Dihydro-5,5-dimethyl-8-(2-phenylethynyl)-2-naphthalenyl]ethenyl]benzoicacid 结构式](https://img.chemicalbook.com/CAS/20180808/GIF/215030-90-3.gif)
4-[(1E)-2-[5,6-Dihydro-5,5-dimethyl-8-(2-phenylethynyl)-2-naphthalenyl]ethenyl]benzoicacid 性质
| 沸点 | 605.4±55.0 °C(Predicted) |
|---|---|
| 密度 | 1.21±0.1 g/cm3(Predicted) |
| 储存条件 | 2-8°C |
| 溶解度 | 二甲基亚砜：≥20mg/mL |
| 酸度系数(pKa) | 4.27±0.10(Predicted) |
| 形态 | 粉末 |
| 颜色 | 浅黄色至厚黄色 |
| InChI | 1S/C29H24O2/c1-29(2)19-18-24(14-10-21-6-4-3-5-7-21)26-20-23(13-17-27(26)29)9-8-22-11-15-25(16-12-22)28(30)31/h3-9,11-13,15-18,20H,19H2,1-2H3,(H,30,31)/b9-8+ |
| InChIKey | YCADIXLLWMXYKW-CMDGGOBGSA-N |
| SMILES | CC1(C)CC=C(C#Cc2ccccc2)c3cc(\C=C\c4ccc(cc4)C(O)=O)ccc13 |
4-[(1E)-2-[5,6-Dihydro-5,5-dimethyl-8-(2-phenylethynyl)-2-naphthalenyl]ethenyl]benzoicacid 用途与合成方法
BMS493 是一种反向泛视黄酸受体 (RARs) 激动剂。BMS493 增加了 RARs 与核共抑制因子的相互作用，还可阻止视黄酸诱导的分化。
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RAR
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BMS493 (100 nM; 6 days; ALDHhi UCB cells) treatment shows a twofold increase in the number of ALDHhi cells available for transplantation compared with untreated controls. Newly expanded ALDHhi cells shows increased numbers of CD34 and CD133-positive cells, as well as a reduction in CD38 expression, a marker of hematopoietic cell differentiation.
Cell Viability Assay
| Cell Line: | ALDHhi UCB cells |
| Concentration: | 100 nM |
| Incubation Time: | 6 days |
| Result: | Showed a twofold increase in the number of ALDHhi cells available for transplantation compared with untreated controls. |
Intrapancreatic transplantation of cell progeny after expansion of ALDHhi cells with or without BMS493 shows no reduction of hyperglycemia in Streptozotocin-treated NOD/SCID mice. Thus, Umbilical cord blood (UCB)-derived ALDHhi cells effectively lost islet regenerative capacity during ex vivo expansion.
4-[(1E)-2-[5,6-Dihydro-5,5-dimethyl-8-(2-phenylethynyl)-2-naphthalenyl]ethenyl]benzoicacid 价格(试剂级)
| 更新日期 | 产品编号 | 产品名称 | CAS号 | 包装 | 价格 |
|---|---|---|---|---|---|
| 2026-09-15 | HY-108529 | 215030-90-3 | 1 mg | 363 | |
| 2026-09-15 | HY-108529 | 4-[(1E)-2-[5,6-Dihydro-5,5-dimethyl-8-(2-phenylethynyl)-2-naphthalenyl]ethenyl]benzoicacid | 215030-90-3 | 5mg | 800 |
4-[(1E)-2-[5,6-Dihydro-5,5-dimethyl-8-(2-phenylethynyl)-2-naphthalenyl]ethenyl]benzoicacid供应商 更多
武汉易泰科技有限公司上海分公司
联系电话： 18930552037
产品介绍：
英文名称：BMS 493;4-[(1E)-2-[5,6-Dihydro-5,5-diMethyl-8-(2-phenylethynyl)-2-naphthalenyl]ethenyl]benzoicacid
CAS：215030-90-3
纯度：99% HPLC
包装信息：1Mg ; 5Mg;10Mg ;100Mg;250Mg ;500Mg ;1g;2.5g ;5g ;10g
Sigma-Aldrich西格玛奥德里奇(上海)贸易有限公司
联系电话：021-61415566 800-8193336
产品介绍：
英文名称：BMS 493
CAS：215030-90-3
纯度：>=98% (HPLC)
包装信息：5mg, 25mg
备注：B6688
江苏艾康生物医药研发有限公司
联系电话：025-66061636 19370895928
产品介绍：
英文名称：(E)-4-(2-(5,5-Dimethyl-8-(phenylethynyl)-5,6-dihydronaphthalen-2-yl)vinyl)benzoic acid
CAS：215030-90-3
纯度：95+%
包装信息：1g;5g;10g
最新发布供应信息
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