SRSF11 (serine/arginine-rich splicing factor 11) is essential for the splicing of exon 10 of tau protein, which is a microtubule-associated protein involved in the survival and function of neurons. Microtubule interfering agents, such as vincristine and paclitaxel, phosphorylate this protein, mediated by CDK (cyclin dependent kinase). This event leads to the arrest of cell cycle at G2/M phase.
