The Janus kinases (JAKs) are protein tyrosine kinases that modulate cytokine signaling during immunological responses and hematopoiesis. JAK family members consist of four isoforms, namely, JAK1, JAK2, JAK3 and TYK2. JAK1 plays a crucial role in mediating the JAK/STAT signaling response to interleukin 6. Alterations in JAK functions have been implicated in heart and immunological disorders, as well as in hematopoietic malignancies . Monoclonal Anti-JAK1 antibody is specific for human JAK1 (approx. 130 kDa).
