c-Fos is a widely expressed nuclear protein and member of the Fos protein family that includes c-Fos, FosB, Fra-1, and Fra-2.1 It is a proto-oncogene that contains a leucine zipper motif to facilitate heterodimerization with Jun family proteins, such as c-Jun, to form the transcription factor complex activator protein-1 (AP-1) that has roles in cell proliferation, differentiation, and apoptosis. Expression of c-fos is induced in response to growth factors, tumor promoters, cytokines, and UV radiation.1,2 In neurons, c-fos expression is induced upon depolarization and is widely used as a marker of neuronal activation.3 c-fos is also overexpressed in a variety of tumor cells, and transgenic overexpression of c-fos in mice induces formation of chondrosarcomas.2,4 Cayman’s c-Fos (N-Term) Rabbit Monoclonal Antibody (Clone RM374) can be used for immunohistochemistry (IHC) and Western blot (WB) applications.WARNING This product is not for human or veterinary use.
