HexylHIBO (hydrobromide)

HexylHIBO is an antagonist of group I metabotropic glutamate receptors (mGluRs; Kbs = 140 and 110 µM for mGluR1α and mGluR5a, respectively).1 It is selective for group I mGluRs over mGluR2 (group II) and mGluR4a (group III) (Kbs = >1,000 µM for both), as well as AMPA, NMDA, and kainate receptors (IC50s = >100 µM for all). HexylHIBO (6.3 and 12.5 mg/kg, i.c.v.) inhibits NMDA-induced seizures in mice. It also potentiates increases in plasma adrenocorticotropic hormone (ACTH) levels in a rat model of restraint stress.2WARNING This product is not for human or veterinary use.

[1] ULF MADSEN. Synthesis and Pharmacology of 3-Isoxazolol Amino Acids as Selective Antagonists at Group I Metabotropic Glutamic Acid Receptors[J]. Journal of Medicinal Chemistry, 2001, 44 7: 1051-1059. DOI: 10.1021/jm000441t
[2] NATHAN K. EVANSON  James P H. Metabotropic glutamate receptor-mediated signaling dampens the HPA axis response to restraint stress[J]. Physiology & Behavior, 2015, 150: Pages 2-7. DOI: 10.1016/j.physbeh.2015.02.027