F9170 (trifluoroacetate salt)

F9170 is an antiviral peptide corresponding to amino acids 789-803 of the HIV-1 envelope glycoprotein.1 It binds to the LLP1 domain within the HIV-1 envelope protein cytoplasmic tail and inhibits HIV-1 IIIB infection of MT-2 cells (EC50 = 0.19 µM). F9170 (3 mg/kg) reduces plasma viral load in a rhesus macaque model of simian HIV (SHIV) infection.WARNING This product is not for human or veterinary use.

[1] QIAN WANG. An amphipathic peptide targeting the gp41 cytoplasmic tail kills HIV-1 virions and infected cells[J]. Science Translational Medicine, 2020, 12 546. DOI: 10.1126/scitranslmed.aaz2254