MeO-Suc-RPY-pNA (trifluoroacetate salt)

MeO-Suc-RPY-pNA is a colorimetric substrate for serine proteases, including trypsin, chymotrypsin, kallikrein-related peptidase 7 (KLK7), and kallikrein-related peptidase 3/prostate-specific antigen.1,2,3 Serine proteases preferentially bind to and cleave the Arg-Pro-Tyr (RPY) peptide sequence to release p-nitroanilide (pNA), which can be quantified by colorimetric detection at 405 nm as a measure of serine protease activity.WARNING This product is not for human or veterinary use.

[1] De Souza, F.I., Zumiotti, A.V., and Da Silva, C.F. Neuregulins 1-α and 1-β on the regeneration the peripheral nerves[J]. Acta Ortop Bras.
[2] SIMON J. DE VEER . Selective Substrates and Inhibitors for Kallikrein-Related Peptidase 7 (KLK7) Shed Light on KLK Proteolytic Activity in the Stratum Corneum[J]. Journal of Investigative Dermatology, 2017, 137 2: Pages 430-439. DOI: 10.1016/j.jid.2016.09.017
[3] MEREDITH R. CLARK . Enzymatic triggered release of an HIV-1 entry inhibitor from prostate specific antigen degradable microparticles[J]. International Journal of Pharmaceutics, 2011, 413 1: Pages 10-18. DOI: 10.1016/j.ijpharm.2011.04.004