2-Methylallyl Iodide is used as a reactant in the preparation of chroman-substituted, tetrahydroquinoline-substituted and thiochroman-substituted ureas and thioureas for their use as anticancer agents.
Methallyl iodide is an unstable but highly reactive alkylating agent that attacks C, N, and S nucleophiles; the products are susceptible to addition reactions, especially electrophilic reactions in C=C systems.
Methallyl iodide is prepared from Methallyl Chloride by reaction with Sodium Iodide in acetone, MEK, or DMF.
Sensitive to light and heat; prepare as required; decomposes appreciably after a few hours. Use in a fume hood.
