MONOCLONAL ANTI-SH2 DOMAIN-CONTAINING LEUKOCYTE PHOSPHOPROTEIN OF 76 KDA

Monoclonal anti-SLP-76 antibody can be used in western blotting to detect SLP-76 protein using Jurkat cell lysate.

SLP-76 (SH2 domain-containing leukocyte phosphoprotein) is a 76kD protein that is expressed mainly in cells of hematopoietic origin. It facilitates TCR signalling and has a pivotal role in TCR-induced tyrosine phosphorylation of phospholipase Cγ, inositol phosphate accumulation, Ca²⁺ mobilization, and ras activation. Monoclonal anti-SLP-76 antibody can be used in immunoprecipitation. Mouse anti-SLP-76 antibody reacts specifically with human SLP-76 protein.