(3S)-3-(5-chloro-2-methoxy-phenyl)-3-fluoro-6-(trifluoromethyl)-1H-ind ol-2-one

Chemical Properties

Boiling point	436.9±45.0 °C(Predicted)
Density	1.50±0.1 g/cm3(Predicted)
storage temp.	Store at -20°C
solubility	Soluble to 100 mM in DMSO and to 100 mM in ethanol
form	Powder
pka	10.43±0.40(Predicted)
color	White to off-white
InChI	InChI=1S/C16H10ClF4NO2/c1-24-13-5-3-9(17)7-11(13)15(18)10-4-2-8(16(19,20)21)6-12(10)22-14(15)23/h2-7H,1H3,(H,22,23)/t15-/m0/s1
InChIKey	ULYONBAOIMCNEH-HNNXBMFYSA-N
SMILES	N1C2=C(C=CC(C(F)(F)F)=C2)[C@@](C2=CC(Cl)=CC=C2OC)(F)C1=O

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Animal Model:	Female NMRI or male C57 mice (20-25 g) (Anxiolytic Models)^[1]
Dosage:	i.p.
Administration:	3, 10, 30 mg/kg
Result:	Significantly and dose dependently increased time spent in the open areas, reduced latency to enter an open area, and increased the number of entries in to the open areas in Zero Maze.