Transient receptor potential cation channel subfamily C member 1 (TRPC1) facilitates Ca2+ entry upon store depletion in a variety of cell types by forming a multimeric complex with other TRPCs. The encoded protein is implicated in the odontoblast-like differentiation of human dental pulp cells (hDPCs). Mutation in the gene is associated with the development type 2 diabetes mellitus (T2D). Decreased expression of the gene leads to hepatocellular carcinoma cell proliferation and thus, TRPC1 can be considered as a potential therapeutic target for hepatocellular carcinoma.
