[(2S,3R,5S,6S)-2,3,4,5,6-pentahydroxycyclohexyl]oxyphosphonic acid

ChEBI: 1D-myo-inositol 1-phosphate is an inositol having myo- configuration substituted at position 1 by a phosphate group. It has a role as a human metabolite, an Escherichia coli metabolite and a mouse metabolite. It is functionally related to a myo-inositol. It is a conjugate acid of a 1D-myo-inositol 1-phosphate(2-).

Inositol, a cyclic molecule with six hydroxyl groups, forms the hydrophobic head group of membrane inositol phospholipids. Inositol phosphates are intracellular second messengers in eukaryotic cells. The most studied of them is inositol1,4,5 triphosphate (IP3) which is said to play an important role in releasing calcium ions from intracellulars tores in endoplasmic reticulum.
Inositol phosphate is considered to be of microbial origin and its various forms are characterized in soil. It can exist in several stereoisomeric forms (a isomeric forms) such as myo, scyllo, neo and chrio.
Inositol hexaphosphoric acid, known as phytic acid, occurs in nature in the seeds of many cereal grains as insoluble calcium or magnesium salts. It inhibits the absorption of calcium in the intestine.

Crystallise the phosphate from water, and EtOH. Recrystallise 1g by dissolving it in 3mL of H2O and adding slowly 15mL of commercial EtOH, filter the crystals, wash with a little EtOH then Et2O and dry it in a vacuum. [McCormick & Carter Biochemical Preparations 2 65 1952.]