DPPE FUMARATE

Product NameDPPE FUMARATE
CAS1185241-83-1
MFC30H28O4P2
MW514.49
EINECS
MOL FileMol File

Chemical Properties

storage temp.	Desiccate at -20°C
solubility	Soluble to 100 mM in sterile water
form	Powder
color	White to off-white

Usage And Synthesis

Uses

Tesmilifene fumarate (DPPE fumarate), an H1C receptor antagonist, potentiates a wide range of cytotoxics and even to offer some protection of normal cells[1][2].

Biological Activity

Binds with high affinity to the antiestrogen binding site but not to the estrogen receptor. An inhibitor of histamine binding at the intracellular histamine (H lc ) site.

in vivo

Tesmilifene (DPPE, 20 mg/kg (s.c.) and 20 μg (icv in 5 μL)) potentiated seizures induced by both convulsants^[2].

Animal Model:	Male BKTO mice (25-45 g)^[2].
Dosage:	20 mg/kg (s.c.) and 20 μg (icv in 5 μL).
Administration:	S.C. and icv.
Result:	Potentiated seizures induced by both convulsants.

References

[1] Mark Vincent, et al. Tesmilifene may enhance breast cancer chemotherapy by killing a clone of aggressive, multi-drug resistant cells through its action on the p-glycoprotein pump. Med Hypotheses. 2006;66(4):715-31. DOI:10.1016/j.mehy.2005.11.005
[2] G Sturman, et al. Modulation of the intracellular and H3-histamine receptors and chemically-induced seizures in mice Agents Actions. 1994 Jun;41 Spec No:C68-9. DOI:10.1007/BF02007771