Jun9-72-2 (CAS 2657659-42-0) is potent inhibitor (IC50 = 670 nM) of SARS-CoV2 papain-like (PL) protease. It showed potent antiviral activity in both Vero E6 (EC50 = 6.62 μM) and Caco2-hACE2 (EC50 = 7.90 μM) cell lines.
Jun9-72-2 is a papain (Plpro) inhibitor of SARS-CoV-2 with an IC50 value of 0.67 μM. Jun9-72-2 has antiviral activity[1].
1.Ma et al. (2021), Discovery of SARS-CoV-2 Papain-like Protease Inhibitors through a Combination of High-Throughput Screening and a FlipGFP-Based Reporter Assay; ACS Cent. Sci., 7 1245