Butanamide, 2-[[3-[2-(1-cyclohexen-1-yl)ethyl]-3,4-dihydro-6,7-dimethoxy-4-oxo-2-quinazolinyl]thio]-N-(4-ethylphenyl)-

K284-6111 is an orally active inhibitor for protein chitinase 3-like 1 (CHI3L1). K284-6111 reduces the expression of inflammatory proteins such as iNOS, COX-2, GFAP, and Iba-1, inhibits β-secretase and NF-κB, and suppresses Aβ production. K284-6111 ameliorates the Aβ1–42-induced mice memory impairment, and can be used in research about Alzheimer’s Diseases[1].

[1] Choi JY, et al., K284-6111 prevents the amyloid beta-induced neuroinflammation and impairment of recognition memory through inhibition of NF-κB-mediated CHI3L1 expression. J Neuroinflammation. 2018 Aug 11;15(1):224. DOI:10.1186/s12974-018-1269-3