4-Pentynoyl-Val-Ala-PAB-PNP

4-Pentynoyl-Val-Ala-PAB-PNP is a cleavable ADC linker, that has been used to synthesis cryptophycin conjugates[1]. 4-Pentynoyl-Val-Ala-PAB-PNP is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

Cleavable Linker

[1] Cedric DESSIN, et al. Cryptophycin compounds and conjugates thereof. WO2022175222