Monoperoxyphthalic Acid is used as a reagent in the synthesis of 4-Hydroxyretinoic Acid (H953300); a novel substrate for human liver microsomal UDP-glucuronosyltransferase(s) and recombinant UGT2B7.
Mild peroxycarboxylic acids for effecting epoxidation of π-bonds, Baeyer-Villiger reactions, and the oxidation of diverse heteroatoms including nitrogen, sulfur, and selenium.
Monoperoxyphthalic acid is prepared as required by the addition of phthalic anhydride to 30% aqueous Hydrogen Peroxide, in the presence of Sodium Hydroxide or Sodium Carbonate. Magnesium monoperoxyphthalate is prepared by the addition of phthalic anhydride and Magnesium Oxide to aqueous hydrogen peroxide.
Drying: magnesium monoperoxyphthalate should be dried over calcium chloride in a desiccator.
Magnesium monoperoxyphthalate may be stored at room temperature. All work should be carried in an efficient fume hood behind a polycarbonate safety screen.
