20.8 parts of 1-phenylcyclopentyl-1-carboxylic acid chloride, obtained from
the acid (cf. Am. Soc. 1934, 56, 715) by means of thionyl chloride, are
dissolved in 250 parts by volume of absolute ether, then, while stirring and
cooling with a mixture of common salt and ice a solution of 12 parts of
diethylaminoethanol in 50 parts by volume of absolute ether is allowed to
drop there into, the temperature being maintained below 0°C, whereupon
stirring is continued during 2 hours at room temperature. The whole is then
twice shaken out with water and once with diluted hydrochloric acid, the
combined aqueous solutions are made alkaline with a potassium carbonate
solution and shaken out with ether. The ethereal solution is washed with
water, dried over potassium carbonate and the solvent is distilled off. The base
boils at a pressure of 0.07 mm at 112°C to 115°C.
The base may then be converted to the hydrochloride or to the
ethanedisulfonic acid salt (edisylate).
