Prezalumab (AMG 557) is a monoclonal antibody targeting ICOSL that has synergistic anti-inflammatory activity with CD28 antibody inhibitors[1].
References
[1] Dillon SR, et al. Non-Redundant Roles of T Cell Costimulation Pathways in Inflammatory Arthritis Revealed by Dual Blockade of ICOS and CD28 with Acazicolcept (ALPN-101). Arthritis Rheumatol. 2023 Aug;75(8):1344-1356. DOI:10.1002/art.42484
