Corynoxine hydrochloride 性质
| 溶解度 | DMF: 30 mg/ml DMSO: 30 mg/ml DMSO: PBS (pH 7.2) (1:4): 0.25 mg/ml Ethanol: 3 mg/ml |
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Corynoxine hydrochloride 用途与合成方法
Corynoxine hydrochloride 是一种从 Uncaria macrophylla 中分离出的四环羟吲哚生物碱。Corynoxine hydrochloride 是一种天然的自噬增强剂，可通过 Akt/mTOR 途径促进 α-突触核蛋白的清除。
Corynoxine (6.25-25 μM; 6-12 h) increases the expression of LC3-II, an autophagy specific marker, in N2a and SH-SY5Y cells in a dose-dependent manner.
Corynoxine (25 μM; 48 h) promotes the degradation of wild type (WT) and mutant (A53T) α-syn in inducible PC12 cells via autophagy induction.
Western Blot Analysis
| Cell Line: | N2a and SH-SY5Y cells |
| Concentration: | 6.25, 12.5, 25 μM |
| Incubation Time: | 6, 12 hours |
| Result: | Induced autophagy in neuronal cell lines. |
Corynoxine (100-100 mg/kg; oral gavage) exhibits prolongation of the thiopental-induced hypnosis in mice.
Corynoxine (10-100 μM for 12 h) induces autophagy in drosophila.
Corynoxine hydrochloride供应商 更多
南京世洲生物科技有限公司
联系电话：025-85560043 15850508050
产品介绍：
英文名称：Corynoxine hydrochloride
纯度：98%
包装信息：10mg 100mg
