基本属性 生物活性靶点体外研究体内研究 用途与合成方法 MSDS TYR-PRO-TRP-PHE-NH2 价格(试剂级) 供应商 供应信息

TYR-PRO-TRP-PHE-NH2

TYR-PRO-TRP-PHE-NH2

中文名称:TYR-PRO-TRP-PHE-NH2
英文名称:ENDOMORPHIN-1
CAS号:189388-22-5
分子式:C34H38N6O5
分子量:610.7
EINECS号:
Mol文件:189388-22-5.mol
TYR-PRO-TRP-PHE-NH2 结构式

TYR-PRO-TRP-PHE-NH2 性质

熔点 144-146℃
沸点 1052.8±65.0 °C(Predicted)
密度 1.343±0.06 g/cm3(Predicted)
RTECS号 SQ7316800
储存条件 −20°C
溶解度 水中≥14.9 mg/mL; DMSO 中≥30.55 mg/mL;乙醇中≥47 mg/mL
酸度系数(pKa) 9.86±0.15(Predicted)
形态 固体
颜色 白色至类白色
水溶解性 Soluble in water
CAS 数据库 189388-22-5(CAS DataBase Reference)

TYR-PRO-TRP-PHE-NH2 用途与合成方法

Endomorphin 1,一种高度选择性的高亲和力μ-opioid受体激动剂 , 对kappa3结合位点具有高亲和力 ,Ki为 20 到 30 nM 之间。

Ki: 20-30 nM (kappa 3 opioid receptor)

Endomorphin 1 (EM-1) is an endogenous opioid peptide and one of the two Endomorphins. It is a high affinity, highly selective agonist of the μ-opioid receptor, and along with Endomorphin 2 (EM-2). The two Endomorphins display reasonable affinities for kappa 3 binding sites, with K i values between 20 and 30 nM. Endomorphin 1 and Endomorphin 2 compete both μ 1 and μ 2 receptor sites quite potently. Endomorphins have little appreciable affinity for either delta or kappa 1 binding sites, with K i values greater than 500 nM.

Both Endomorphin 1 and Endomorphin 2 are potent analgesics with peak effects seen at 10 and 15 min, respectively. All subsequent studies are performed at peak effect. Both compounds are fully active supraspinally and spinally, with no indication of ceiling effects. Endomorphin 1 is significantly more potent spinally than supraspinally and, at the spinal level, it is significantly more potent than Endomorphin 2. The response of both agents are readily reversed by naloxone. β-FNA, a highly selective μ antagonist, effectively reverses the actions of both Endomorphins. Both Endomorphin 1 and Endomorphin 2 display a profile similar to morphine. Neither compound have analgesic activity in CXBK mice at a dose which produced over 70% analgesia in control CD-1 mice.

安全信息

WGK Germany3

MSDS信息

语言:English
提供商:SigmaAldrich

TYR-PRO-TRP-PHE-NH2 价格(试剂级)

更新日期 产品编号 产品名称 CAS号 包装 价格
2024-11-08 HY-P0185 TYR-PRO-TRP-PHE-NH2 189388-22-5 5mg 500
2024-11-08 HY-P0185 TYR-PRO-TRP-PHE-NH2 189388-22-5 10mM * 1mLin Water 672

TYR-PRO-TRP-PHE-NH2供应商 更多

杭州固拓生物科技有限公司
现货
联系电话:0571-88211921 13735575465
产品介绍:
中文名称:内吗啡-1
英文名称:Endomorphin-1
CAS:189388-22-5
纯度:98% HPLC
包装信息:1mg;10mg;100mg;1g;100g
备注:研发级
库存量:60mg
现货日期:2024/11/25 10:00:53
绍兴市均宇生物科技有限公司
现货
联系电话:0571-88211921 15572296305
产品介绍:
中文名称:内吗啡-1
英文名称:Endomorphin-1
CAS:189388-22-5
纯度:99% HPLC MS
包装信息:1mg;5mg;10mg;100mg;500mg;1kg;5kg;25kg
备注:科研级
库存量:60mg
现货日期:2024/11/26 10:58:03
浙江杰坤生物科技有限公司
现货
联系电话:0571-88211951 13735575465
产品介绍:
中文名称:内吗啡-1
英文名称:Endomorphin-1
CAS:189388-22-5
纯度:99% HPLC MS
包装信息:1mg;5mg;10mg;100mg;500mg;1kg;5kg;25kg
备注:科研级
库存量:60mg
现货日期:2024/11/18 16:13:21
武汉易泰科技有限公司上海分公司
联系电话:821-50328103-801 18930552037
产品介绍:
英文名称:EndoMorphin-1
CAS:189388-22-5
纯度:99% HPLC
包装信息:1Mg ; 5Mg;10Mg ;100Mg;250Mg ;500Mg ;1g;2.5g ;5g ;10g
吉尔生化(上海)有限公司
联系电话:21-61263452 13641803416
产品介绍:
英文名称:Endomorphin-1;YPWF-NH2
CAS:189388-22-5
纯度:95% HPLC 98% HPLC
包装信息:1mg,5mg,10mg,25mg,100mg,1g,10g

最新发布供应信息

189388-22-5
绍兴市均宇生物科技有限公司 2024-11-28
内吗啡-1/189388-22-5/Endomorphin-1
上海鸿肽生物科技有限公司 2024-11-16