RNF128, also known as gene related to anergy in lymphocytes, is a RING finger protein family E3 ubiquitin ligase that participates in T cell anergy induction. RNF128 is a type I transmembrane protein, made up of a zinc RING finger, coiled-coil, and protease-associated domain. Expression of RNF128/GRAIL has been shown to inhibit cytokine transcription and CD4 T cell proliferation, as well as regulate naïve T cell tolerance induction and Treg cell function.
[1] Anandasabapathy, N. et al. (2003) Immunity 18, 535-47.
[2] Lineberry, N.B. et al. (2008) J Immunol 181, 1622-6.
[3] Nurieva, R.I. et al. (2010) Immunity 32, 670-80.
[4] Whiting, C.C. et al. (2011) FEBS J 278, 47-58.
