Pertussis Toxin from Bordetella pertussis (lyophilized, salt free)

Pertussis toxin was first isolated from B. pertussis and is used to study G protein-coupled receptor signaling in cells and experimental autoimmune encephalomyelitis (EAE) in animals. Pertussis toxin catalyzes the transfer of the ADP-ribose moiety of NAD to the α subunits of heterotrimeric Gi/o proteins, resulting in the receptors being uncoupled from Gi/o proteins.1,2 Pertussis toxin is also used as an adjuvant, given with specific antigens, to immunize animals and induce EAE, an animal model of multiple sclerosis.3,4WARNING This product is not for human or veterinary use.

[1] HARVEY R. KASLOW  Dr usilla L B. Pertussis toxin and target eukaryotic cells: binding, entry, and activation[J]. FASEB Journal, 1992, 6 9: 2684-2690. DOI: 10.1096/fasebj.6.9.1612292
[2] UI M. Islet-activating protein, pertussis toxin: a probe for functions of the inhibitory guanine nucleotide regulatory component of adenylate cyclase[J]. Trends in pharmacological sciences, 1984, 67 1: 277-279. DOI: 10.1016/0165-6147(84)90444-9
[3] KAITLYNN R. DAVENPORT . Site-directed immobilization of a genetically engineered anti-methotrexate antibody via an enzymatically introduced biotin label significantly increases the binding capacity of immunoaffinity columns[J]. Journal of Chromatography B, 2016, 1021: Pages 114-121. DOI: 10.1016/j.jchromb.2016.01.021
[4] FRANCESCA RONCHI. Experimental priming of encephalitogenic Th1/Th17 cells requires pertussis toxin-driven IL-1β production by myeloid cells.[J]. Nature Communications, 2016: 11541. DOI: 10.1038/ncomms11541