Diquat-d12 (bromide)

Diquat-d12 is intended for use as an internal standard for the quantification of diquat (Item No. 26251) by GC- or LC-MS. Diquat is a bipyridylium herbicide that, as a stable radical, acts as an electron acceptor in the electron transport chain and is reoxidized by molecular oxygen, producing reactive oxygen species (ROS).1 Diquat administration has been used to induce oxidative stress in vitro and in animal models.2,3,4 It increases the production of ROS and decreases the mitochondrial membrane potential in mitochondria isolated from porcine intestine leading to mitophagy when administered at a dose of 100 mg/kg.2 Formulations containing diquat have been used in agriculture for crop desiccation and defoliation.WARNING This product is not for human or veterinary use.

[1] RAO V S. Mechanisms of Action of Herbicides[C]. 2000: 0. DOI: 10.1201/9781482279603-10
[2] SHUTING CAO. Diquat-induced oxidative stress increases intestinal permeability, impairs mitochondrial function, and triggers mitophagy in piglets.[J]. Journal of animal science, 2018, 96 5: 1795-1805. DOI: 10.1093/jas/sky104
[3] PREETI SINGH C M M Peter S Hanson. Sirtuin-2 Protects Neural Cells from Oxidative Stress and Is Elevated in Neurodegeneration.[J]. Parkinson’s Disease, 2017, 2017: 2643587. DOI: 10.1155/2017/2643587
[4] OLDŘICH TOMÁŠEK. Opposing effects of oxidative challenge and carotenoids on antioxidant status and condition-dependent sexual signalling[J]. Scientific Reports, 2016, 6 1. DOI: 10.1038/srep23546