Hirsutide is a cyclotetrapeptide fungal metabolite produced by the entomopathogenic fungus
Hirsutella.
1 It has antibacterial activity against
C. pyogenes, S. aureus, P. aeruginosa, and
K. pneumonia (MICs = 25, 13, 6, and 21 μg/cm
3, respectively).
2 Hirsutide also has antifungal activity against
C. albicans, M. audouinii, A. niger, and
Ganoderma (MICs = 13, 6, 25, and 6 μg/cm
3, respectively).
1. Lang, G., Blunt, J.W., Cummings, N.J., et al. Hirsutide, a cyclic tetrapeptide from a spider-derived entomopathogenic fungus, Hirsutella sp J. Nat. Prod. 68(8),1303-1305(2005).
2. Dahiya, R., Kumar, A., and Maheshwari, M. Toward the synthesis and biological evaluation of hirsutide Montash. Chem. 140(1),121-127(2009).
