m-PEG3-Sulfone-PEG3-t-butyl ester is a PEG linker containing sulfone and t-butyl ester moieties. The sulfone can react with thiol groups of proteins. The t-butyl can be removed under acidic conditions. The hydrophilic PEG linker increases the water solubility of the compound in aqueous media.
Uses
m-PEG3-Sulfone-PEG3-Boc is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].
IC 50
PEGs
References
[1] An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562 DOI:10.1016/j.ebiom.2018.09.005
