bpV(phen) (potassium hydrate)
bpV(phen) (potassium hydrate)
bpV(phen) (potassium hydrate) 性质
储存条件 | Store at -20°C |
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溶解度 | DMSO:1mg/mL; PBS(pH 7.2):10 mg/mL |
形态 | 结晶固体 |
颜色 | 黄至橙色 |
bpV(phen) (potassium hydrate) 用途与合成方法
IC50: 38 nM (PTEN), 343 nM (PTP-β) and 920 nM (PTP-1B)
Parasite
Leishmania
Apoptosis
bpV(phen) (5 μM; 24.5 hours; H9c2 cells) treatment causes a further decrease of cell viability in H/R-injured H9c2 cells.
bpV(phen) (5 μM; 24.5 hours; H9c2 cells) treatment increases the apoptosis of H/R-injured H9c2 cells.
bpV(phen) (5 μM; 24.5 hours; H9c2 cells) treatment significantly promotes the accumulation of cytoplasmic Cytochrome C in H/R-injured H9c2 cells.
After stimulation of bpV(phen), PTEN-induced putative kinase protein 1 (PINK1)/Parkin-mediated mitophagy is inhibited.
bpV(phen) is an insulin-mimetic agent following insulin-receptor tyrosine kinase hyperphosphorylation and activation.
Cell Viability Assay
Cell Line: | Hypoxia/reoxygenation (H/R)-injured H9c2 cells |
Concentration: | 5 μM |
Incubation Time: | 24.5 hours (hypoxia for 24 h; reoxygenation for 30 minutes) |
Result: | Caused a further decrease of cell viability. |
Apoptosis Analysis
Cell Line: | Hypoxia/reoxygenation (H/R)-injured H9c2 cells |
Concentration: | 5 μM |
Incubation Time: | 24.5 hours (hypoxia for 24 h; reoxygenation for 30 minutes) |
Result: | Increased the apoptosis of H/R-injured H9c2 cells. |
Western Blot Analysis
Cell Line: | Hypoxia/reoxygenation (H/R)-injured H9c2 cells |
Concentration: | 5 μM |
Incubation Time: | 24.5 hours (hypoxia for 24 h; reoxygenation for 30 minutes) |
Result: | Showed an increased release of Cytochrome C. |
bpV(phen) (5 mg/kg; intraperitoneal injection; daily; for 38 days; male BALB/c nude (nu/nu) athymic mice) treatment causes a significant reduction in average tumor volume.
Animal Model: | Male BALB/c nude (nu/nu) athymic mice (6-7 weeks old) injected with PC-3 cells |
Dosage: | 5 mg/kg |
Administration: | Intraperitoneal injection; daily; for 38 days |
Result: | Caused a significant reduction in average tumor volume. |
bpV(phen) (potassium hydrate) 价格(试剂级)
更新日期 | 产品编号 | 产品名称 | CAS号 | 包装 | 价格 |
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2024-11-08 | HY-122818 | bpV(phen) (potassium hydrate) | 171202-16-7 | 5mg | 650 |
2024-11-08 | HY-122818 | 10 mM * 1 mLin Water | 715 |