Bis-PEG1-PFP ester

Bis-PEG1-PFP ester is a PEG linker with two PFP ester moieties. The PFP ester is amine-reactive, stable compound. PFP esters are less susceptible toward hydrolysis compared to NHS esters. The PEG linker increases the water solubility of compounds in aqueous environments.

Bis-PEG1-PFP ester is a non-cleavable (1 unit PEG) ADC linker used in the synthesis of antibody-drug conjugates (ADCs)[1].

Non-cleavable Linker

[1] CORTEZ, Alex, et al. ANTIBODY CONJUGATES COMPRISING TOLL-LIKE RECEPTOR AGONIST. WO2017072662A1.