(5Z)-7-OXOZEAENOL
(5Z)-7-OXOZEAENOL 性质
| 熔点 | 171-173 °C(Solv: dichloromethane (75-09-2); hexane (110-54-3)) |
|---|---|
| 沸点 | 666.8±55.0 °C(Predicted) |
| 密度 | 1.270±0.06 g/cm3(Predicted) |
| 储存条件 | 2-8°C |
| 溶解度 | 二甲基亚砜：>10mg/mL |
| 酸度系数(pKa) | 7.32±0.70(Predicted) |
| 形态 | 粉末 |
| 颜色 | 白色至类白色 |
| InChI | 1S/C19H22O7/c1-11-5-3-7-14(20)18(23)15(21)8-4-6-12-9-13(25-2)10-16(22)17(12)19(24)26-11/h3-4,6-7,9-11,15,18,21-23H,5,8H2,1-2H3/b6-4+,7-3-/t11-,15-,18+/m0/s1 |
| InChIKey | NEQZWEXWOFPKOT-BYRRXHGESA-N |
| SMILES | COc1cc(O)c2C(=O)O[C@@H](C)CC=CC(=O)[C@@H](O)[C@@H](O)C\C=C\c2c1 |
(5Z)-7-OXOZEAENOL 用途与合成方法
|
TAK1 8.1 nM (IC 50 ) |
VEGFR-2 52 nM (IC 50 ) |
VEGFR-3 110 nM (IC 50 ) |
FLT3 170 nM (IC 50 ) |
PDGFR-β 340 nM (IC 50 ) |
B-RAF VE 6300 nM (IC 50 ) |
SRC 6600 nM (IC 50 ) |
MEK1 411 nM (IC 50 ) |
5Z-7-Oxozeaenol is a potent irreversible and selective inhibitor of transforming growth factor (TGF)-β-activated kinase 1 (TAK1, IC 50 , 8.1 nM), less active on MEK1 (IC 50 , 411 nM). 5Z-7-Oxozeaenol prevents inflammation by inhibiting the catalytic activity of TAK1 MAPK kinase kinase. 5Z-7-Oxozeaenol is also an inhibitor of VEGF-R2, with an IC 50 of 52 nM. 5Z-7-Oxozeaenol has inhibitory activity against VEGF-R3, FLT3, PDGFR-β, B-RAF VE and SRC, with IC 50 s of 110, 170, 340, 6300 and 6600 nM, respectively. 5Z-7-Oxozeaenol inhibits JNK/p38 paythway, but it is not a direct inhibitor and is signal specific. 5Z-7-Oxozeaenol suppresses the PMA-induced AP-1 activity almost to the basal level in the KT cells, but has no effects on IL-1-induced NF-kB activity in the KK cells.
(5Z)-7-OXOZEAENOL 价格(试剂级)
| 更新日期 | 产品编号 | 产品名称 | CAS号 | 包装 | 价格 |
|---|---|---|---|---|---|
| 2026-09-15 | HY-12686 | (5Z)-7-OXOZEAENOL | 253863-19-3 | 1 mg | 2500 |
| 2026-09-15 | HY-12686 | (5Z)-7-OXOZEAENOL | 253863-19-3 | 10 mM * 1 mL in DMSO | 10450 |
