Oxidized low-
density lipoprotien (oxLDL) particles contain low molecular weight species which are cytotoxic and pro-
atherogenic.
1 Many of these substances were recently isolated and purified from oxLDL, and identified as phosphatidylcholine species containing a fragmented, oxidized short-
chain fatty acid remnant at the
sn-
2 position.
2 1-
(Palmitoyl)-
2-
(5-
keto-
6-
octene-
dioyl) phosphatidylcholine, or KOdiA-
PC, is one of the most potent CD36 ligands among the oxLDL species.
3 KOdiA-
PC confers CD36 scavenger receptor binding affinity to LDL at a frequency of only 2 to 3 KOdiA-
PC molecules/LDL particle, and may be one of the more important structural determinants of oxLDL.
1. Podrez, E.A., Febbraio, M., Sheibani, N., et al. Macrophage scavenger receptor CD36 is the major receptor for LDL modified by monocyte-generated reactive nitrogen species J. Clin. Invest. 105(8),1095-1108(2000).
2. Podrez, E.A., Poliakov, E., Shen, Z., et al. A novel family of atherogenic oxidized phospholipids promotes macrophage foam cell formation via the scavenger receptor CD36 and is enriched in atherosclerotic lesions J. Biol. Chem. 277(41),38517-38523(2002).
3. Podrez, E.A., Poliakov, E., Shen, Z., et al. Identification of a novel family of oxidized phospholipids that serve as ligands for the macrophage scavenger receptor CD36 J. Biol. Chem. 277(41),38503-38516(2002).
