Cysteinyl leukotriene receptor 2 (CysLT2) is a G protein-coupled receptor that mediates the actions of leukotriene C4 (LTC4), LTD4, and, to a lesser extent, LTE4.1 It is expressed primarily in the heart, placenta, spleen, lymph nodes, and peripheral blood leukocytes.1,2 Signaling induced by LTC4 through the CysLT2 receptor induces the production of chemokines via NF-κB and AP-1 activation in endothelial cells, indicating a role in inflammation.3 A CysLT2 receptor containing a leucine-to-glutamine substitution at position 129 (L129Q) has been found in human uveal melanoma cells and is associated with tumorigenesis in vivo.4,5 SNPs in CYSLTR2 are associated with aspirin intolerance in patients with asthma.6 Cayman’s CysLT2 Receptor (N-Term) Polyclonal Antibody can be used for ELISA, flow cytometry (FC), and Western blot (WB) applications.WARNING This product is not for human or veterinary use.
