基本属性 生物活性靶点体外研究体内研究 用途与合成方法 R-雌马酚 价格(试剂级) 供应商 供应信息 相关产品

R-雌马酚

R-雌马酚

中文名称:R-雌马酚
英文名称:R-Equol
CAS号:221054-79-1
分子式:C15H14O3
分子量:242.27
EINECS号:
Mol文件:221054-79-1.mol
R-雌马酚 结构式

R-雌马酚 性质

熔点 184-187 °C
沸点 441.7±45.0 °C(Predicted)
密度 1.286±0.06 g/cm3(Predicted)
溶解度 DMF:10mg/mL; DMSO:20mg/mL;乙醇:20mg/mL;乙醇:PBS (pH 7.2) (1:10): 0.1 mg/mL
形态 结晶固体
酸度系数(pKa) 9.94±0.40(Predicted)
颜色 白色至黄色

R-雌马酚 用途与合成方法

(R)-Equol 是 ERα 和 ERβ 的激动剂,Ki 值分别为 27.4 和 15.4 nM。

Ki: 27.4 nM (ERα), 15.4 nM (ERβ)

(R)-Equol is an agonist of both ERα and ERβ with K i s of 27.4 and 15.4 nM, respectively. (R)-Equol induces a dose-dependent inhibitory effect on the invasive capacity of MDA-MB-231 cells that is significant at the highest concentration tested (50 μM). Following 48-h exposure to (R)-Equol, invasion is reduced by 62% (p=0.009, versus untreated cells) with 50 μM (R)-Equol. Matrix metalloproteinase-2 (MMP-2) expression is significantly down-regulated following treatment with 50 μM (R)-Equol (p=0.035).

Animals fed (R)-Equol have a significantly reduced number of palpable tumors over time when compare with Controls (P=0.002). Furthermore, the number of palpable tumors formed per rat in the (R)-Equol-fed group is significantly lower than that of rats treated with S-(-)equol (P=0.008). (R)-Equol-fed animals have 43% fewer tumors than the control group and this difference is highly statistically significant (P=0.004). The number of tumors/tumor-bearing animal is significantly lower in the animals fed (R)-Equol compare with Controls (3.3±0.4 versus 5.5±0.5, P=0.004). At necropsy, the mean (±SEM) tumor weight per animal for (R)-Equol fed rats (5.3±1.1 mg) is significantly reduced (P=0.04) when compare with Controls (9.9±1.4 mg). Feeding the (R)-Equol diet results in significantly increased tumor latency (P=0.003).

R-雌马酚 价格(试剂级)

更新日期 产品编号 产品名称 CAS号 包装 价格
2024-11-08 HY-108414 R-雌马酚 221054-79-1 5mg 770
2024-11-08 HY-108414 R-雌马酚 221054-79-1 10mM * 1mLin DMSO 847

R-雌马酚供应商 更多

上海佰世凯化学科技有限公司
联系电话:+86-21-20908456
产品介绍:
中文名称:(R)-雌马酚
英文名称:(R)-Equol
CAS:221054-79-1
纯度:98%+
包装信息:50mg;100mg;500mg;1g;5g
备注:Biochemical Reagents; Pharmaceutical Intermediates
大赛璐药物手性技术(上海)有限公司
联系电话:021-50460086-9 15921403865
产品介绍:
中文名称:(R)-雌马酚
英文名称:(R)-Equol; (3R)-3,4-Dihydro-3-(4-hydroxyphenyl)-2H-1-benzopyran-7-ol
CAS:221054-79-1
纯度:95%/98%
包装信息:1G;100G; 1KG
备注:100151
上海御略医药科技有限公司
联系电话:021-60345187 13671753212
产品介绍:
CAS:221054-79-1
纯度:98%
包装信息:100g;500g;1kg;5kg
上海凯睿生物科技有限公司
联系电话:021-5068 3667/17749785980/1029026415; 17749785980
产品介绍:
英文名称:R-Equol
CAS:221054-79-1
纯度:97%
包装信息:100mg,1g,100g,1kg
备注:试剂级
滁州市科迈尔化工科技有限公司
联系电话:0550-5196001 15000891977
产品介绍:
中文名称:R-雌马酚
英文名称:R-Equol
CAS:221054-79-1
纯度:98%HPLC
包装信息:1mg,10mg,100mg,500mg,1g,10g

最新发布供应信息

R-雌马酚|T13443|TargetMol
TargetMol中国(陶术生物) 2024-12-12

"R-雌马酚"相关产品信息