4-bromo-2-fluoro-6-methylbenzonitrile

4-?Bromo-?2-?fluoro-?6-?methylbenzonitrile is used to synthesize novel 5-phenylpyridin-2(1H)-one derivatices, which are potent and orally available reversible agent with satisfactory Bruton’s tyrosin kinase inhibitors, cellular and arthritis inhibiton in vivo.