a-Helical Corticotropin Releasing Factor (12-41)

a-Helical Corticotropin Releasing Factor (12-41) is a 30 amino acids long, α-helical analogue of corticotropin releasing factor/hormone. Corticotropin releasing factor (CRF) is a hypothalamic hormone, which stimulates the secretion of adrenocorticotrophic hormone (ACTH). a-Helical Corticotropin Releasing Factor (12-41) would suppress the stimulatory effect[1][2].

[1] Hennessy MB, et al. Evidence that endogenous corticotropin-releasing factor suppresses behavioral responses of guinea pig pups to brief isolation in novel surroundings. Dev Psychobiol. 1997 Jul;31(1):39-47. DOI:10.1002/(sici)1098-2302(199707)31:1<39::aid-dev4>3.0.co;2-v
[2] Ellis M J, et al. The effects of corticotrophin-releasing hormone, arginine vasopressin and their antagonists on ACTH release from perifused horse anterior pituitary cells[J]. Journal of endocrinology, 1994, 143(1): 85-93.