ZONIPORIDE DIHYDROCHLORIDE
英文名称:ZONIPORIDE DIHYDROCHLORIDE
CAS号:241800-97-5
分子式:C17H17ClN6O
分子量:356.81
EINECS号:
Mol文件:241800-97-5.mol
ZONIPORIDE DIHYDROCHLORIDE 性质
储存条件 | Desiccate at -20°C |
---|---|
溶解度 | 乙醇中≤1mg/ml;DMSO中10mg/ml;二甲基甲酰胺中10mg/ml |
形态 | 结晶固体 |
稳定性 | 吸湿性 |
ZONIPORIDE DIHYDROCHLORIDE 用途与合成方法
Zoniporide (CP-597396) hydrochloride 是 1 型钠氢交换剂 (NHE-1) 的有效和选择性抑制剂。Zoniporide hydrochloride 抑制人 NHE-1 (IC50=14 nM),与其他 NHE 亚型相比具有大于 150 倍的选择性,并有效抑制离体 NHE-1 依赖性的人血小板溶胀 (IC50=59 nM)。
IC50: 14 nM (NHE-1)
Zoniporide (0.25-4 mg/kg; i.v.; every hour for 2 hours) elicits a dose-dependent reduction in infarct size (ED
50
=0.45 mg/kg/h) in open chest anesthetized rabbits.
Zoniporide exhibits moderate plasma protein binding, has a t
1/2
of 1.5 hours in monkeys, and has one major active metabolite.
Zoniporide treatment shows the AUC
0-∞
and t
1/2
are 0.07 μg h/mL and 0.5 hours, respectively.
Animal Model: | Rabbit |
Dosage: | 0.25, 1, 4 mg/kg |
Administration: | Every hour for 2 hours; intravenous injection |
Result: | Elicited a significant dose-dependent reduction in infarct size in the anesthetized rabbit. The ED 50 was 0.45 mg/kg/h. |
Animal Model: | Rat |
Dosage: | 1 mg/kg |
Administration: | Intravenous injection(Pharmacokinetic Analysis) |
Result: | The AUC 0-∞ and t 1/2 were 0.07 μg h/mL and 0.5 hours, respectively. |
ZONIPORIDE DIHYDROCHLORIDE供应商 更多
武汉易泰科技有限公司上海分公司
联系电话:821-50328103-801 18930552037
产品介绍:
英文名称:Zoniporide dihydrochloride;[1-(Quinolin-5-yl)-5-cyclopropyl-1H-pyrazole-4-carbonyl]guanidinedihydrochloride
CAS:241800-97-5
纯度:99% HPLC
包装信息:1Mg ; 5Mg;10Mg ;100Mg;250Mg ;500Mg ;1g;2.5g ;5g ;10g
上海一飞生物科技有限公司
联系电话:021-65675885 18964387627
产品介绍:
英文名称:Zoniporide (hydrochloride)
CAS:241800-97-5
纯度:99%
包装信息:1mg;5mg;10mg
备注:试剂级
ChemeGen 中国
联系电话: 18818260767
产品介绍:
英文名称:Zoniporide hydrochloride
CAS:241800-97-5
纯度:98%
包装信息:10 mg;50 mg;100 mg;500 mg;1 g;5 g;10 g
备注:品牌:ChemeGen
MedBio脉铂医药
联系电话:021-69568360 18916172912
产品介绍:
英文名称:ZONIPORIDE DIHYDROCHLORIDE
CAS:241800-97-5
纯度:98%
包装信息:50mg; 5mg; 10mg
备注:Medbio
天津普西唐生物医药科技有限公司
联系电话:010-60605840 15801484223;
产品介绍:
英文名称:Zoniporide Hydrochloride
CAS:241800-97-5
纯度:98%
包装信息:5mg